Abstract
Author(s): Mahendrasinh M. Raj1*, Hemul V. Patel2,Lata M. Raj3and Naynika K. Patel4
In the present study, novel Thiadiazoles were synthesized by reaction of benzoic and 2-hydroxybenzoic acid with thiosemicarbazide to synthesize 5-phenyl-1,3,4-thiadiazol-2-amine(A)and 2-(5-amino-1,3,4-thiadiazole-2-yl) phenol(B).From these compounds various derivatives of 1,3,4-Thiadiazole derivatives (A1-A4 and B1-B4) have been synthesized. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H NMR, and nitrogen estimation. These compounds were screened for antibacterial (Staphylococcusaureus ATCC 9144,Becillus Cereus ATCC11778,Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853and anti-fungal (Aspergillus niger ATCC 9029 and Aspergillus fumigatus ATCC 46645) by paper disc diffusion technique.