Abstract
Author(s): Geetha Bhaktha1*,Shivananda Nayak1and Manjula Shantaram2
Asian Indians have more visceral fat and a greater insulin resistance. Obesity is associated with a low-grade inflammation of adipose tissue resulting in activation of the cytokine system which leads to exaggerated insulin resistance, impaired glucose tolerance and even vascular complications. Leptin, known to control the appetite has also been shown to regulate the glucose level. TNF-α also has been suggested as the linkbetween obesity, diabetes and atherosclerosis.In our study we explored the level of leptin and TNF-α with BMI among the different BMI groups in females of type 2 diabetes. Seventy three diabetic females free from micro and macro vascular disorders were recruited. They were assessed for physical and chemical parameters like Body Mass Index, TNF-α and leptin.The relation looks more linear when regressionline was plotted with leptin in the BMI range of 30-35. But this relation was lost (BMI>30-35) when TNF-α and BMI were plotted suggesting the practical limitations of TNF-α. Though the clinical appearance of vascular complications did not exist, the correlation between leptin and anthropometric variable clearly suggests a positive link between obesity (inflammation) and metabolic syndrome and it remains even before the appearance of clinical manifestation of the vascular complications. Thusa relation of leptin with the anthropometric variables along with the TNF-α in female diabetics without any micro and macro vascular complication has ensured the understanding of the interdependence of these markers in different levels of obesity.