Abstract
Author(s): Biswajit Batabyal,Shibendu Biswas*,PritiD.Desai and Sukanta Chakraborty
Although the main reservoir of Candida spp. is believed to be the buccal mucosa, thesemicroorganisms can co aggregate with bacteria insub gingival bio film and adhere to epithelial cells. Suchinteractions are associated with the capacity of Candida spp. to invade gingival conjunctive tissue, and may be important in the microbial colonization that contributes to progression of oral alterations caused by diabetesmellitus, some medications, and immunosuppressive diseases such as AIDS. In addition, immune deficiency can result in proliferation of Candida spp. And germination of forms that are more virulent and have a higher capacity to adhere to and penetrate cells inhost tissues. The virulence factors of Candida spp. increase host susceptibility to proliferation of these microorganisms and are likely to be important in thestudy of periodontal disease. Herein, we briefly review the literature pertaining to the role of Candida spp. In periodontal disease, and consider the main virulencefactors, the host immune response to these microorganisms, and the effect of concomitant immunosuppressive conditions
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