Abstract
Author(s): TS. Sandozi Tasneem
Insulin was discovered in 1921 by a surgeon, Dr.Frederick Banting, and Charles Best, a medical student after experimenting on a number of dogs in Toronto, Canada. It was possible for these two scientists to successfully demonstrate the blood lowering effect of insulin only by the assistance of John Macleod,a Professor of Physiologyand Bertram Collip, a Biochemistwho offered them their services and laboratory to carry out the experiments. In 1923 they were awarded the Nobel Prize for their discovery. The last one decade has seen the introduction of a variety of newer insulins prepared in different formulations by r DNA technology with distinct pharmacokinetic profiles. Consequently these newer insulins can be better accommodated in the management of diabetesmellitus and yield better blood sugar control. This would also go a long way in minimizing the complications associated with long duration diabetes mellitus.