Abstract
Author(s): Arghya A Roy*, Kshitija R Kakade, Laxmikant N Barde and Vijay B Mathur
Non-polymeric biodegradable implants for post operative site delivery were developed and evaluated in vitro. The glyceryl monostearate (GMS) based cephalexin pellets were formulated using compression and molding technique with different percentage of erosion enhancers like polyethylene glycol (PEG 6000 and PEG 400) and propylene glycol and the effect of these parameters on drug release pattern from non polymeric matrix were studied. These formulations were subjected to in vitro drug release by USP dissolution method. The pellets without PEG 400 showed about 52.0% drug release in 30 h while pellets containing 5.0% PEG showed 66.0% drug release (prepared by compression technique) in same time; while same formulation prepared by molding technique showed 81.0% drug release. In case of propylene glycol in similar concentration (5.0%) showed 75.0% drug release by compression technique and 83.0%drug release by molding technique in 30 h. The formulations containing maximum amount of erosion enhancer which can be compressed to form pellets i.e.5.0% PEG 400 or propylene glycol, were further subjected to in vitro drug release by agar gel method and stability studies. It was observed that glyceryl monostearate forms hydrophobic matrix and haddelayed the drug delivery. It was observed that the release profile was dependent on the combination and percentage of erosion enhancers and preparation technique. The formulation prepared by compression method showed more delayed release compared to formulations prepared by molding method.