Abstract
Author(s): V. Vasu Naik, CH. Bala Markonda* , A. Anka Rao and M. Prasuli
The aim of the present study was to prepare and evaluate matrix type transdermal patches of Rosiglitazone Maleate by using Ethylcellulose and Eudragit as polymers at different combinations to minimize adverse effects associated with oral administration. Transdermal patches of Rosiglitazone Maleate were prepared by solvent evaporation method by varying the blend ratios of Ethylcellulose and Eudragit. The drug polymer interaction studies were carried out by FT-IR studies. The prepared patches were evaluated for their thickness, weight variation, folding endurance, percentage moisture absorption, percentage moisture loss and drug content. In vitro drug release was determined by using Franz diffusion cell in phosphate buffer (pH5.4). The release data was studied for various kinetic parameters to understand the mechanism of drug release from the developed formulations. IR studies revealed that the drug, polymer and excipients were compatible with each other. Thin, flexible, smooth and uniform films were obtained with Eudragit and ethyle cellulose using dibutyl phthalate as plasticizer. Thickness, weights and drug contents of all the formulations remained almost uniform with low SD values. The formulations E6, E7 formulated by incorporating 1% span 80 and tween 80. E5 showed good release of drug than another formulations. Formulation E5 was prepared by combination of ethyl cellulose and Eudragit in the ratio of 1 :(1:5) the release rate of drug is 99.95 in 24hrs. Studies have shown promising results and there is a scope for further pharmacokinetic evaluation.