Abstract
Author(s): S.Ramu*,S.Rambabu, D.Srinivasa Rao andG. Rama Krishna
The objective of the present study is to “optimize, formulate and evaluatesustained-release (SR) matrix tablets of timolol maleate’’.A controlled drug delivery system is usually designed to deliver the drug at particular rate, safe and effective blood levels are maintained for a period as long as the system continues to deliver the drug. The present work is aimed at preparingand evaluating sustained-release (SR) matrix tablets of timolol maleate (TM). The Preparation contains 40 formulationsof timolol maleate (TM) by using different polymers like hydroxypropylmethylcellulose (HPMC K15M, HPMC K100M CR), polyethylene oxide (PEO), ethylcellulose (EC), and Kollidon-SR. Microcrystalline cellulose (MCC), lactose were used as diluents. Magnesium stearate (MS) 1% and talc 2 % were used as lubricants. 5% w/v solution of polyvinylpyrrolidone (PVP-K90) in isopropyl alcohol (IPA) was used as binder. The sustained-release (SR) matrix tablets of timolol maleate (TM) were prepared by wet granulation and direct compression methods.The prepared batches ofmatrix tablets of timolol maleatecan be evaluated forpre compression parameters likebulk density, tapped density, carr’s index, hausner`s ratio, and angle of repose and physical evaluation of tablets like weight variation, thickness, hardness test, drug content, In -Vitrodissolution studies,swelling and erosion studies. Among all the formulations Optimized formulation F23 (drug to polymer ratio 1:2) which includes both HPMC K100M and EC (1:1) has successfully sustained the drug release for 12 hours and the drug release pattern was similar to theoretical release profile