Abstract
Author(s): Chandrasekhara Rao Baru*, S.Vidyadhara, KV.Raghavendra Rao, K.Vanitha Prakash and B.Umashankar
The present study of Ibuprofen Floating tablets were to develop optimized gastric floating drug delivery system(GFDDS) by using various polymers like HPMC K4M and Carbopol 940 to enhance the bioavailability and therapeutic efficacy of ibuprofen Various approaches have been followed to encourage gastric retention of an oral dosage form. Floating systems have low bulk density so that they can float on the gastric juice in the stomach.The present work attempts have been made to prepare Ibuprofen by Direct compression method,4 formulations (F1 to F4) floating tablets of Ibuprofen were prepared using variable concentrations of HPMCE5M and Carbopol940,buoyancy lag time and the total floating time was studied for all the formulations,The compatibility evaluations were performed by DSC analysis. Studies imply that polymers are compatible with each other. There was no interaction found between polymer and drug.The research was undertaken with the aim to formulate and characterize the sustained release floating tablets of Ibuprofen using HPMCK4M and Carbopol 940 as polymers.