Abstract
Author(s): Padmakshi Singh
From medicinal plant Solanum nigrum (Solanaceae) phytochemically extracted glycoalkaloid from its CHCl3 fraction by column chromatography. Spectral study and Co-TLC authenticate the structure of active principle Solasodine (C27H43NO2). It has been claimed that Solanum nigrum particular of an excellent remedy for liver disorder. Present investigation is therefore to determine the effect of active compound Solasodine on protein content of liver and kidney after daily administration of dose at the level of 2 to 6 mg/kg b.wt. in albino rats for 4, 6 and 8 days respectively. It was noticed that the chronic administration for longer duration leads to significant increase in protein contents of liver and kidney. It has quicker response then alcoholic extract of whole plant. It is assume that increase in protein content rapidly it also inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis through synthesis of variety of protein.