Abstract
Author(s): Jharana Mallick1*,Debashrita Sahoo2, Durga Madhab Kar3and Jagruti Makwana4
An investigation into the suitability of alginate beads of microspheres for oral delivery of Ibuprofen is presented. Alginate beads microspheres were formulated under different conditions of polymer concentration at constant speed. The microspheres were evaluated according to particle size, drug content, percentage yield, moisture content by Karl Fischer titration, bulk density, tapped density, Carr’s index. In vitro release of Ibuprofen from the microspheres was studied in simulated intestinal fluid (SIF, pH 7.4). The release data was fitted into two release models to investigate the mechanism of Ibuprofen release from the microspheres. All the microspheres showed good swelling characteristics in distilled water. The investigation revealed that the microspheres produced with 2.5% (W/V) sodium alginate had the optimum prolonged release pattern. The microspheres produced using 2% (W/V) Sodium alginate had the highest delayed release of the incorporated drug, whereas other ratios of drug polymer had the fastest release. The Invitro dissolution studies appeared to have adequately described the release process as about 8 to 10 hours. The Scanning Electron Microscopic study revealed the spherical shape and the presence of pores which is effective for loading of the dose. The X-Ray diffraction study showed a normal graph which represents no drug polymer interaction. Differential Scanning Calorimeter, Thermo gravimetric analysis and FTIR spectroscopy also reveals no possibility of interaction between drug and polymers used in the study. This implies that formulations of Ibuprofen-sodium alginate microspheres are likely to offer a reliable means of delivering Ibuprofen by the oral route.